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AlphaFold-MCP-Server

AlphaFold-MCP-Server is an MCP server, listed under databases. Its repository has 36 GitHub stars and is licensed under NOASSERTION; we last read it on 2026-10-22.

This server offers access to the AlphaFold Protein Structure Database using the Model Context Protocol (MCP) and includes tools and resources for protein structure prediction analysis.

Install

MCP servers are packaged differently from each other -- some run via npx, some as a Docker image, some as a plain script you clone and run. AlphaFold-MCP-Server’s own README did not state one plainly enough for this page to quote it rather than guess, so it will not guess. The repository below states it.

What it reaches, and what it needs

Reaches
○ not recognised
Credential
○ none found

Maintenance

Stars
36
State
listed
Licence
NOASSERTION
From the repository

A comprehensive Model Context Protocol (MCP) server that provides access to the AlphaFold Protein Structure Database through a rich set of tools and resources for protein structure prediction analysis.

What AlphaFold-MCP-Server can do

19 tools documented in its README. An AI client calls these by name.

get_structure
Retrieve AlphaFold structure prediction for a specific UniProt ID.
download_structure
No description in the README.
check_availability
Check if AlphaFold structure prediction is available for a UniProt ID.
search_structures
Search for available AlphaFold structures by protein name or gene.
list_by_organism
List all available structures for a specific organism.
get_organism_stats
Get statistics about AlphaFold coverage for an organism.
get_confidence_scores
Get per-residue confidence scores for a structure prediction.
analyze_confidence_regions
Analyze confidence score distribution and identify high/low confidence regions.
get_prediction_metadata
Get metadata about the prediction including version, date, and quality metrics.
batch_structure_info
Get structure information for multiple proteins simultaneously.
batch_download
Download multiple structure files.
batch_confidence_analysis
Analyze confidence scores for multiple proteins.
compare_structures
Compare multiple AlphaFold structures for analysis.
find_similar_structures
Find AlphaFold structures similar to a given protein.
get_coverage_info
Get information about sequence coverage in the AlphaFold prediction.
validate_structure_quality
Validate and assess the overall quality of an AlphaFold prediction.
export_for_pymol
Export structure data formatted for PyMOL visualization.
export_for_chimerax
Export structure data formatted for ChimeraX visualization.
get_api_status
No description in the README.

Read from the README; names are kept only if the README contains them.

AlphaFold-MCP-Server compared with similar servers

AlphaFold-MCP-Server compared with the closest alternatives, by services reached, credentials, stars, last update and licence
ServerReachesNeedsStarsLast updateLicence
AlphaFold-MCP-Server (this page)—None listed362025-12-21NOASSERTION
CodeGraphContextneo4jNEO4J_PASSWORD4,3602026-10-22MIT
dbhubmysql, postgres, sqliteNone listed3,7022026-10-21MIT
mcp-server-mysqlmysqlNone listed2,1732026-07-27MIT
mysql_mcp_servermysqlMYSQL_PASSWORD1,4022026-08-02MIT
servermysqlMYSQL_ROOT_PASSWORD8742025-08-09MIT

Ranked by services in common with AlphaFold-MCP-Server, then by stars. Figures are from each repository when we last read it.

Common questions about AlphaFold-MCP-Server

What does AlphaFold-MCP-Server do?
This server offers access to the AlphaFold Protein Structure Database using the Model Context Protocol (MCP) and includes tools and resources for protein structure prediction analysis.
How do I install AlphaFold-MCP-Server?
Its README did not state an install command plainly enough for us to quote one, so we do not guess. The repository has the instructions: https://github.com/Augmented-Nature/AlphaFold-MCP-Server
Is AlphaFold-MCP-Server official and is it maintained?
We found nothing naming it as a vendor’s official server. Its repository has 36 GitHub stars and its state in our directory is listed. Its last commit we recorded was on 2025-12-21.
What licence does AlphaFold-MCP-Server use?
The repository declares the NOASSERTION licence.

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